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The ketogenic diet: Pros and cons - PubMed

2020.11.16 14:09



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Title & authors Abstract Comment in Similar articles Cited by Publication types Related information LinkOut - more resources Title & authors Abstract Comment in Similar articles Cited by Publication types Related information LinkOut - more resources Review Atherosclerosis Actions Search in PubMed Search in NLM Catalog Add to Search . 2020 Jan;292:119-126. doi: 10.1016/j.atherosclerosis.2019.11.021. Epub 2019 Nov 28.

The ketogenic diet: Pros and cons

Blair O Neill 1 , Paolo Raggi 2 Affiliations Expand

Affiliations

1 Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada; Department of Medicine, University of Alberta, Edmonton, AB, Canada; Division of Cardiology, University of Alberta, Edmonton, AB, Canada. 2 Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada; Department of Medicine, University of Alberta, Edmonton, AB, Canada; Division of Cardiology, University of Alberta, Edmonton, AB, Canada. Electronic address: [email protected] PMID: 31805451 DOI: 10.1016/j.atherosclerosis.2019.11.021 Item in Clipboard Review

The ketogenic diet: Pros and cons

Blair O Neill et al. Atherosclerosis . 2020 Jan . Show details Display options Display options Format Abstract PubMed PMID Atherosclerosis Actions Search in PubMed Search in NLM Catalog Add to Search . 2020 Jan;292:119-126. doi: 10.1016/j.atherosclerosis.2019.11.021. Epub 2019 Nov 28.

Authors

Blair O Neill 1 , Paolo Raggi 2

Affiliations

1 Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada; Department of Medicine, University of Alberta, Edmonton, AB, Canada; Division of Cardiology, University of Alberta, Edmonton, AB, Canada. 2 Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada; Department of Medicine, University of Alberta, Edmonton, AB, Canada; Division of Cardiology, University of Alberta, Edmonton, AB, Canada. Electronic address: [email protected] PMID: 31805451 DOI: 10.1016/j.atherosclerosis.2019.11.021 Item in Clipboard Full-text links Cite Display options Display options Format Abstract PubMed PMID

Abstract

Diets have been at the center of animated debates for decades and many claims have been made in one direction or the other by supporters of opposite camps, often with limited evidence. At times emphasis has been put on a single new aspect that the previous diets had overlooked and the new one was to embrace in order to improve weight loss and well-being. Unfortunately, very few randomized clinical trials involving diets have addressed the combined question of weight loss and cardiovascular outcomes. The recently introduced ketogenic diet requires a rigorous limitation of carbohydrates while allowing a liberal ingestion of fats (including saturated fats) and has generated a flurry of interest with many taking the pro position and as many taking the cons position. The ketogenic diet causes a rapid and sensible weight loss along with favourable biomarker changes, such as a reduction in serum hemoglobin A1c in patients with diabetes mellitus type 2. However, it also causes a substantial rise in low density lipoprotein cholesterol levels and many physicians are therefore hesitant to endorse it. In view of the popular uptake of the keto diet even among subjects not in need of weight loss, there is some preoccupation with the potential long-term consequences of a wide embrace of this diet by large segments of the population. On the contrary, numerous lines of evidence show that plant-based diets are associated with reduction in oncological and cardiovascular diseases and a prolonged life span. The debate reproduced in this article took place during a continuous medical education program between two cardiologists with largely differing views on the matter of effectiveness, sustainability, and safety of the ketogenic diet compared to alternative options.

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Comments on "The ketogenic diet: Pros and cons". Dafoe W, Gyenes GT. Dafoe W, et al. Atherosclerosis. 2020 Mar;296:1. doi: 10.1016/j.atherosclerosis.2020.01.005. Epub 2020 Jan 20. Atherosclerosis. 2020. PMID: 31999983 No abstract available.

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Dietary Energy Partition: The Central Role of Glucose. Remesar X, Alemany M. Remesar X, et al. Int J Mol Sci. 2020 Oct 19;21(20):7729. doi: 10.3390/ijms21207729. Int J Mol Sci. 2020. PMID: 33086579 Free PMC article. Review. Intermittent Fasting as a Trigger of Ketoacidosis in a Patient With Stable, Long-term Type 1 Diabetes. Fernández-Cardona A, González-Devia D, Mendivil CO. Fernández-Cardona A, et al. J Endocr Soc. 2020 Aug 22;4(10):bvaa126. doi: 10.1210/jendso/bvaa126. eCollection 2020 Oct 1. J Endocr Soc. 2020. PMID: 33033790 Free PMC article. Short-Term Physiological Effects of a Very Low-Calorie Ketogenic Diet: Effects on Adiponectin Levels and Inflammatory States. Monda V, Polito R, Lovino A, Finaldi A, Valenzano A, Nigro E, Corso G, Sessa F, Asmundo A, Nunno ND, Cibelli G, Messina G. Monda V, et al. Int J Mol Sci. 2020 May 2;21(9):3228. doi: 10.3390/ijms21093228. Int J Mol Sci. 2020. PMID: 32370212 Free PMC article. Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States. Dąbek A, Wojtala M, Pirola L, Balcerczyk A. Dąbek A, et al. Nutrients. 2020 Mar 17;12(3):788. doi: 10.3390/nu12030788. Nutrients. 2020. PMID: 32192146 Free PMC article. Review.

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